Current surgical and medical treatment options for single ventricle physiology conditions
remain palliative. On the long term, despite treatment, the systemic ventricle has
a significant risk of developing failure. There are unmet needs to develop novel treatment
modalities to help ameliorate the ventricular dysfunction. Advances in the field of
stem cell therapy have been promising for the treatment of heart failure. Numerous
stem cell populations have been identified. Preclinical studies in small and large
animal models provide evidence for effectiveness of this treatment modality and reveal
several mechanisms of action by which stem cells exert their effect. Many clinical
trials have been designed to further investigate the therapeutic potential that stem
cell therapy may hold for pediatric populations with single ventricle physiology.
In this review, we discuss the stem cell types used in these populations, some preclinical
studies, and the clinical trials of stem cell therapy in single ventricle patients.
Keywords
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Article info
Footnotes
Funding: This work is supported by grants from the National Institute of Health to S. Kaushal (HL141922, HL139060, HL145644, HL118491-06A1) and M. Abdullah (T32 AR 007592). M. Gunasekaran (2018-MSCRFF-4326 & 2020-MSCRFD-5338) and R. Mishra (2018-MSCRFD-4329) were supported by the Maryland Stem Cell Research Foundation. S. Sharma (18CDA34110282) was supported by the American Heart Association Career Development Award.
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